National Radiobiology Archives
Argonne National Laboratory (ANL)
The ANL life span dog studies in the NRA collection include the 1960 144Ce, 1961 137Cs, and the 1968 60Co external gamma ray studies. These studies were designed to compare the toxicity of injected biologically soluble radioisotopes such as 137Cs, which irradiate the whole body more or less uniformly, with injected biologically insoluble radioisotopes such as 144Ce, which is preferentially retained in the phagocytic cells of the reticuloendothelial system including bone marrow, and whole body irradiation using an external gamma source. Data tables available from these studies include breeding history, kennel identification, body weight, biopsy, histopathology, and cause of death records for 688 experimental and 144 control animals.
Extensive external exposure studies of various strains of rodents were conducted at ANL. Those conducted between 1953 and 1970 (when the JANUS reactor program started) were documented by Dr. Doug Grahn in ANL-94-26. The JANUS neutron and gamma studies of B6CF1 mice are described in ANL-95-3. The data from these studies is available at the National Radiobiology Archives.
Tissue specimens (slides and blocks) from the ANL dog and rodent studies are available at Northwestern University. Visit Northwestern University's online Beagle Dog Tissue Archive to search available organs and tissues and to request samples.
Brookhaven National Laboratory (BNL)
Data tables from the radiation leukemogenesis studies performed by Dr. Eugene Cronkite on mice using low dose x or gamma irradiation have been given to the NRA. Likewise, data tables from Dr. Victor Bond's neutron induced leukemogenesis study in some 10,000 mice exposed to low dose rate neutrons of varying energies are also included in the NRA collection. However, since the BNL investigators are still actively working to complete their analyses of these experiments, these files are currently unavailable for external release.
Colorado State University (CSU)
These beagle dog studies were designed to evaluate the effects induced by either prenatal or early post natal exposure to whole body 60Co gamma radiation. Although the principal disease data are not SNODOG- coded, the data tables include histopathology, and cause of death data for 3360 life span and control animals.
Pacific Northwest National Laboratory (PNNL)
The PNNL life span dog studies initiated in 1959 were designed to evaluate the induction of cancer by the inhalation of plutonium in a variety of physicochemical forms including 239PuO2, 238PuO2 , or 239Pu(NO3)4. The Archives have detailed histopathology, clinical data, and an undetermined number of histopathology slides and paraffin blocks from 2176 life span and ancillary animals. The PNNL rodent studies on the other hand were designed to define the shape of the dose-response curve for lung tumor induction in rats following inhalation of 239PuO2. Data tables for 3631 young adult SPF Wister females, including 1070 sham-exposed controls, are available.
University of California at Davis (UCD)
The UCD life span dog studies were conducted using external exposure to x-rays and internal exposures to 90Sr or 226Ra. Tumor induction and life span shortening were the focus of the acute x-ray exposure experiments. Studies were also performed with strontium to evaluate its toxicity and health risks from 90Sr fallout. In addition, life span studies with 226Ra were designed to simulate the ingestion of radium by the radium dial painters. The Archives have individual health summary data, paraffin blocks, and histopathology slides from 1437 dogs, including 218 control animals, from the 90Sr and 226Ra studies.
Inhalation Toxicology Research Institute (ITRI)
The ITRI life span beagle dog studies began in the 1960's and included inhalation exposures to various radionuclides including 90Sr, 144Ce, 90Y, 91Y, and 137Cs. In the 1970's, ITRI initiated experiments with 238Pu and 239Pu that were designed to help resolve the 'hot particle controversy'. The NRA holdings include individual summaries for some 1500 of these life span animals including 225 controls. Some studies and data analyses are still ongoing and these records and data files have been promised to the NRA when the research is completed. Twelve separate rodent studies have been conducted at ITRI over the years and are in various stages of completion. Electronic data files and records of the following studies are scheduled for transfer to the NRA soon:
- Effects of Repeated Inhalation Exposure of Mice to Aerosols of 144CeO2
- Effects of Repeated Inhalation Exposure of Mice to Aerosols of 239PuO2
- Production of Liver Cancer and Chromosome Aberrations by Thorotrast and 239Pu citrate
- Effects of Repeated Inhalation Exposure of Rats to Aerosols of 144CeO2
- Effects of Repeated Inhalation Exposure of Rats to Aerosols of 239PuO2
- Cytogenetic Effects of Inhaled 244Cm2O3 in Rats
- Pulmonary Carcinogenicity of Relatively Low Doses of Beta Irradiation from Inhaled 144CeO2 in Rats
- Effects of Thoracic and Whole- Body Exposure of Rats to X-rays
- Effects of Combined Exposure of Rats to 239PuO2 and Whole-Body X-Radiation
- Carcinogenicity of Inhaled 239PuO2 and Beryllium Metal in Rats
- Effects of Inhaled 239PuO2 and Cigarette Smoke in Rats
- Effects of Combined Exposure of Rats to Inhaled 239PuO2 and a Chemical Carcinogen (NNK)
Lawrence Berkeley Laboratory (LBL)
Metabolism and toxicity studies on primates using 237Np, 237Pu, 238Pu, 241Am, and 90Sr were carried out at LBL by Dr. Patricia W. Durbin. The study with 90Sr was the most comprehensive of the five studies of long-term metabolism in the Rhesus monkey. The NRA holdings include individual animal summary data including uptake and other biokinetic information on bones, plasma, and excreta, from 192 animals. However, the data are sequestered until LBL has completed their analyses.
Oak Ridge National Laboratory (ORNL)
To date, two of the ORNL gamma ray life span studies on mice, one initiated in 1977 using 4728 animals and the second in 1987 using 5037 animals, have been donated to the NRA. The main focus of these studies was to evaluate the ability of gamma irradiation to induce cancer. The NRA holds individual summary information and histopathology data on these 9765 mice.
Data from a third study conducted before 1979, in which 19,200 RFM mice were exposed to a single exposure combination of 137Cs followed by gamma irradiation at ten weeks, are also available.
University of Utah
In the early 1950's, the Radiobiology Laboratory at the University of Utah began a series of life span studies in dogs using a variety of radionuclides including: 239Pu, 226Ra, 228Ra, 228Th, 90Sr, 241Am, 249Cf, 252Cf, 253Es, and 224Ra. These studies were designed to elucidate the health risks and other deleterious effects resulting from exposure to these radionuclides. The Archives have individual animal summary information and histopathology data on 1248 life span animals including 132 controls.
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